Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-ß<sub>25-35</sub> Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action.

Seong, Su Hui; Paudel, Pradeep; Jung, Hyun Ah; Choi, Jae Sue

Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-ß_25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action.

Seong, Su Hui; Paudel, Pradeep; Jung, Hyun Ah; Choi, Jae Sue.

Affiliation

Seong SH; Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. seongsuhui@naver.com.
Paudel P; Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. phr.paudel@gmail.com.
Jung HA; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Korea. jungha@jbnu.ac.kr.
Choi JS; Department of Food and Life Science, Pukyong National University, Busan 48513, Korea. choijs@pknu.ac.kr.

Mar Drugs ; 17(11)2019 Oct 23.

Article in En | MEDLINE | ID: mdl-31652867

Subject(s)

Amyloid beta-Peptides/antagonists & inhibitors; Benzofurans/chemistry; Benzofurans/pharmacokinetics; Dioxins/chemistry; Dioxins/pharmacokinetics; Glycation End Products, Advanced/antagonists & inhibitors; Benzofurans/pharmacology; Dioxins/pharmacology; Lipid Peroxidation/drug effects; Molecular Docking Simulation; Molecular Structure; Phaeophyceae/chemistry; Phloroglucinol/chemistry; Phloroglucinol/pharmacology; Protein Aggregation, Pathological

Key words

phlorotannin, amyloid-ß aggregation, insulin glycation, dynamic simulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Amyloid beta-Peptides / Glycation End Products, Advanced / Dioxins Type of study: Prognostic_studies Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2019 Type: Article

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