Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents.

Luo, Wen; Lv, Jian-Wu; Wang, Ting; Zhang, Zhi-Yang; Guo, Hui-Yan; Song, Zhi-Yi; Wang, Chao-Jie; Ma, Jing; Chen, Yi-Ping

Luo, Wen; Lv, Jian-Wu; Wang, Ting; Zhang, Zhi-Yang; Guo, Hui-Yan; Song, Zhi-Yi; Wang, Chao-Jie; Ma, Jing; Chen, Yi-Ping.

Affiliation

Luo W; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Lv JW; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Wang T; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Zhang ZY; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Guo HY; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Song ZY; Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng 475004, People's Republic of China.
Wang CJ; Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Ma J; Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng 475004, People's Republic of China. Electronic address: majing.1988.ok@163.com.
Chen YP; School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, People's Republic of China. Electronic address: yipchen2009@foxmail.com.

Bioorg Med Chem ; 28(1): 115190, 2020 01 01.

Article in En | MEDLINE | ID: mdl-31744779

Subject(s)

Alzheimer Disease/drug therapy; Cholinesterase Inhibitors/pharmacology; Methoxsalen/analogs & derivatives; Acetylcholinesterase/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Peptides/antagonists & inhibitors; Animals; Behavior, Animal/drug effects; Butyrylcholinesterase/metabolism; Cell Survival/drug effects; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Dose-Response Relationship, Drug; Electrophorus; Hep G2 Cells; Horses; Humans; Male; Methoxsalen/chemical synthesis; Methoxsalen/chemistry; Methoxsalen/pharmacology; Mice; Molecular Structure; PC12 Cells; Peptide Fragments/antagonists & inhibitors; Rats; Structure-Activity Relationship

Key words

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Graveolinine; ß-amyloid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholinesterase Inhibitors / Alzheimer Disease / Methoxsalen Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article

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