Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells.

Liao, Yangjie; Duan, Bo; Zhang, Yufei; Zhang, Xinmin; Xia, Bin

Liao, Yangjie; Duan, Bo; Zhang, Yufei; Zhang, Xinmin; Xia, Bin.

Affiliation

Liao Y; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Duan B; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Zhang Y; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Zhang X; BioInfoRx, Inc., Madison, Wisconsin 53719.
Xia B; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China binxia@pku.edu.cn.

J Biol Chem ; 294(52): 20009-20023, 2019 12 27.

Article in En | MEDLINE | ID: mdl-31748416

Subject(s)

Autophagy; Endoplasmic Reticulum Stress; Intracellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Unfolded Protein Response; Adenine/analogs & derivatives; Adenine/pharmacology; Apoptosis/drug effects; Autophagosomes/metabolism; Autophagy/drug effects; Autophagy-Related Proteins/genetics; Autophagy-Related Proteins/metabolism; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum Stress/drug effects; Endoribonucleases/metabolism; HeLa Cells; Humans; Indoles/pharmacology; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Intracellular Signaling Peptides and Proteins/genetics; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/genetics; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Protein Serine-Threonine Kinases/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Unfolded Protein Response/drug effects; Up-Regulation/drug effects; Vesicular Transport Proteins/genetics; Vesicular Transport Proteins/metabolism

Key words

Bcl-xL inhibitor; ER-phagy; FAM134B; Z36; autophagy; cell death; endoplasmic reticulum (ER); endoplasmic reticulum stress (ER stress); reticulophagy regulator 1 (RETREG1); unfolded protein response (UPR)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Intracellular Signaling Peptides and Proteins / Unfolded Protein Response / Endoplasmic Reticulum Stress / Membrane Proteins Limits: Humans Language: En Journal: J Biol Chem Year: 2019 Type: Article Affiliation country: China

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