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Polyhydroxylated sterols from Monascus purpureus-fermented rice.
Li, Jin-Jie; Zhong, Xiang-Jian; Wang, Xin; Yang, Xi-Miao; Yue, Jian-Yu; Zhang, Xuan; Liu, Jia-Chen; Wang, Kai-Qi; Shang, Xiao-Ya.
Affiliation
  • Li JJ; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Zhong XJ; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Wang X; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Yang XM; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Yue JY; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Zhang X; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Liu JC; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Wang KQ; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China.
  • Shang XY; Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100191, PR China. Electronic address: shangxiaoya@buu.edu.cn.
Steroids ; 154: 108546, 2020 02.
Article in En | MEDLINE | ID: mdl-31758964
ABSTRACT
Using a cell-based cytotoxicity assay, two new polyhydroxylated sterols, 16(S),22(S)-epoxy-3ß,5α,6ß,20(R),23(R),25-hexahydroxy-7-ergostene and 3ß,7ß,8α,25-tetrahydroxy-5,22E-ergostadiene were isolated from the ethyl acetate portion of the ethanolic extract of Monascus purpureus. Their structures were elucidated by spectroscopic analysis and in comparison with those reported in the literature. Both compounds showed cytotoxic activity against the lung adenocarcinoma (A549) with IC50 values of 12.6 and 18.5 µM, exhibited moderate activities against human ovarian cancer (A2780), with IC50 values of 8.8 and 9.4 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oryza / Sterols / Monascus / Fermentation / Antineoplastic Agents Limits: Humans Language: En Journal: Steroids Year: 2020 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oryza / Sterols / Monascus / Fermentation / Antineoplastic Agents Limits: Humans Language: En Journal: Steroids Year: 2020 Type: Article