Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.

Hans, Friederike; Glasebach, Hanna; Kahle, Philipp J

Hans, Friederike; Glasebach, Hanna; Kahle, Philipp J.

Affiliation

Hans F; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Glasebach H; Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, University of Tübingen, 72076 Tübingen, Germany.
Kahle PJ; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany philipp.kahle@uni-tuebingen.de.

J Biol Chem ; 295(3): 673-689, 2020 01 17.

Article in En | MEDLINE | ID: mdl-31780563

Subject(s)

DNA-Binding Proteins/genetics; Heat-Shock Proteins/genetics; Oxidative Stress/genetics; Ubiquitination/genetics; Acetylcysteine/pharmacology; Adenine/analogs & derivatives; Adenine/pharmacology; Amyotrophic Lateral Sclerosis/genetics; Amyotrophic Lateral Sclerosis/pathology; DNA-Binding Proteins/chemistry; Frontotemporal Dementia/genetics; Frontotemporal Dementia/pathology; Glycogen Synthase Kinase 3 beta/genetics; HEK293 Cells; Heat-Shock Proteins/chemistry; Humans; Indoles/pharmacology; Mutation/drug effects; Osmotic Pressure/drug effects; Protein Aggregation, Pathological/genetics; Protein Transport/genetics; Signal Transduction/drug effects; Solubility/drug effects; Sorbitol/pharmacology

Key words

RNA splicing; TAR DNA-binding protein 43 (TDP-43) (TARDBP); amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease); frontotemporal dementia; osmotic shock; oxidative stress; protein aggregation; protein kinase; signal transduction; stress granule; ubiquitylation (ubiquitination)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / DNA-Binding Proteins / Ubiquitination / Heat-Shock Proteins Limits: Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article Affiliation country: Germany

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