Antineoplastic Combined Chemotherapy Protocols/pharmacology; Melanoma/drug therapy; Proto-Oncogene Proteins B-raf/genetics; Pyroptosis/drug effects; Skin Neoplasms/drug therapy; Animals; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Cell Line, Tumor/transplantation; Dendritic Cells/drug effects; Dendritic Cells/immunology; Disease Models, Animal; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; Drug Resistance, Neoplasm/immunology; Female; Humans; Immune Checkpoint Inhibitors/pharmacology; Immune Checkpoint Inhibitors/therapeutic use; Male; Melanoma/genetics; Melanoma/immunology; Mice; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases/metabolism; Mutation; Proof of Concept Study; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Proto-Oncogene Proteins B-raf/metabolism; Pyroptosis/genetics; Pyroptosis/immunology; Skin Neoplasms/genetics; Skin Neoplasms/immunology; Tumor Microenvironment/drug effects; Tumor Microenvironment/genetics; Tumor Microenvironment/immunology