Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases.

Hu, Ming-Ming; Shu, Hong-Bing

Hu, Ming-Ming; Shu, Hong-Bing.

Affiliation

Hu MM; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China; email: mmhu@whu.edu.cn, shuh@whu.edu.cn.
Shu HB; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China; email: mmhu@whu.edu.cn, shuh@whu.edu.cn.

Annu Rev Immunol ; 38: 79-98, 2020 04 26.

Article in En | MEDLINE | ID: mdl-31800327

Subject(s)

DNA/immunology; Immunity, Innate; Animals; Autoimmune Diseases/etiology; Autoimmune Diseases/metabolism; Autoimmunity; Biomarkers; Cytoplasm/immunology; Cytoplasm/metabolism; Disease Susceptibility; Host-Pathogen Interactions/immunology; Humans; Immune Evasion; Interferon Type I/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Nucleotidyltransferases/metabolism

Key words

DNA; MITA/STING; cGAS; cell compartment; immune diseases; innate immunity; type I interferons; viral infection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Immunity, Innate Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Annu Rev Immunol Year: 2020 Type: Article

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