The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.

Shohayeb, Belal; Ho, Uda; Yeap, Yvonne Y; Parton, Robert G; Millard, S Sean; Xu, Zhiheng; Piper, Michael; Ng, Dominic C H

Shohayeb, Belal; Ho, Uda; Yeap, Yvonne Y; Parton, Robert G; Millard, S Sean; Xu, Zhiheng; Piper, Michael; Ng, Dominic C H.

Affiliation

Shohayeb B; Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.
Ho U; Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.
Yeap YY; Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.
Parton RG; Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Australia.
Millard SS; Centre for Microscopy and Microanalysis, The University of Queensland, St Lucia 4072, Australia.
Xu Z; Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.
Piper M; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Ng DCH; Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.

Hum Mol Genet ; 29(2): 248-263, 2020 01 15.

Article in En | MEDLINE | ID: mdl-31816041

Subject(s)

Cell Cycle Proteins/metabolism; Cilia/metabolism; Ciliopathies/genetics; Microcephaly/genetics; Microtubule-Associated Proteins/metabolism; Neocortex/metabolism; Nerve Tissue Proteins/metabolism; Tumor Suppressor Proteins/metabolism; Animals; Anophthalmos/embryology; Anophthalmos/genetics; Anophthalmos/metabolism; Apoptosis/genetics; CRISPR-Cas Systems; Cell Cycle Proteins/genetics; Cells, Cultured; Cilia/genetics; Cilia/pathology; Ciliopathies/embryology; Ciliopathies/metabolism; Ciliopathies/pathology; Dwarfism/embryology; Dwarfism/genetics; Dwarfism/metabolism; Ependymoglial Cells/cytology; Ependymoglial Cells/metabolism; Ependymoglial Cells/pathology; Fibroblasts/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcephaly/embryology; Microcephaly/metabolism; Microtubule-Associated Proteins/genetics; Mutation, Missense; Neocortex/embryology; Nerve Tissue Proteins/genetics; Neurogenesis/genetics; Neuroglia/cytology; Neuroglia/metabolism; Neurons/metabolism; Tumor Suppressor Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cilia / Cell Cycle Proteins / Neocortex / Tumor Suppressor Proteins / Ciliopathies / Microcephaly / Microtubule-Associated Proteins / Nerve Tissue Proteins Type of study: Risk_factors_studies Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2020 Type: Article Affiliation country: Australia

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