Antibody Fragment F(ab')<sub>2</sub> Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention.

Li, Qing; Peterson, Norman; Hanna, Richard N; Kuszpit, Kyle; White, Jason; Allen, Kevin L; Barnes, Arnita; Rickert, Keith W; Shan, Lu; Wu, Herren; Dall'Acqua, William F; Tsui, Ping; Borrok, M Jack

Antibody Fragment F(ab')₂ Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention.

Li, Qing; Peterson, Norman; Hanna, Richard N; Kuszpit, Kyle; White, Jason; Allen, Kevin L; Barnes, Arnita; Rickert, Keith W; Shan, Lu; Wu, Herren; Dall'Acqua, William F; Tsui, Ping; Borrok, M Jack.

Mol Pharm ; 17(2): 507-516, 2020 02 03.

Article in En | MEDLINE | ID: mdl-31841002

Subject(s)

Antibodies, Monoclonal/immunology; Caveolae/metabolism; Drug Carriers/pharmacokinetics; Immunoglobulin Fab Fragments/immunology; Kidney/drug effects; Membrane Proteins/immunology; Animals; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/pharmacokinetics; Antibody Affinity; Drug Carriers/administration & dosage; Female; HEK293 Cells; Humans; Immunoglobulin Fab Fragments/administration & dosage; Kidney/metabolism; Lung/drug effects; Lung/metabolism; Mice; Mice, Inbred BALB C; Tissue Distribution

Key words

PET/CT imaging; antibody fragment F(ab')2; confocal imaging; ex vivo fluorescence imaging system; kidney targeting; plasmalemma vesicle-associated protein; targeted delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Drug Carriers / Caveolae / Kidney / Membrane Proteins / Antibodies, Monoclonal Type of study: Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2020 Type: Article

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