Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.

Zhang, Ya; Wu, Xuefeng; Kai, Yan; Lee, Chia-Han; Cheng, Fengdong; Li, Yixuan; Zhuang, Yongbao; Ghaemmaghami, Javid; Chuang, Kun-Han; Liu, Zhuo; Meng, Yunxiao; Keswani, Meghana; Gough, Nancy R; Wu, Xiaojun; Zhu, Wenge; Tzatsos, Alexandros; Peng, Weiqun; Seto, Edward; Sotomayor, Eduardo M; Zheng, Xiaoyan

Zhang, Ya; Wu, Xuefeng; Kai, Yan; Lee, Chia-Han; Cheng, Fengdong; Li, Yixuan; Zhuang, Yongbao; Ghaemmaghami, Javid; Chuang, Kun-Han; Liu, Zhuo; Meng, Yunxiao; Keswani, Meghana; Gough, Nancy R; Wu, Xiaojun; Zhu, Wenge; Tzatsos, Alexandros; Peng, Weiqun; Seto, Edward; Sotomayor, Eduardo M; Zheng, Xiaoyan.

Affiliation

Zhang Y; GW Cancer Center and.
Wu X; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Kai Y; GW Cancer Center and.
Lee CH; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Cheng F; GW Cancer Center and.
Li Y; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Zhuang Y; Department of Physics, George Washington University Columbian College of Arts and Sciences, Washington, DC, USA.
Ghaemmaghami J; GW Cancer Center and.
Chuang KH; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Liu Z; Department of Biochemistry and Molecular Medicine.
Meng Y; GW Cancer Center and.
Keswani M; Division of Hematology and Oncology, Department of Medicine, and.
Gough NR; GW Cancer Center and.
Wu X; Department of Biochemistry and Molecular Medicine.
Zhu W; GW Cancer Center and.
Tzatsos A; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Peng W; GW Cancer Center and.
Seto E; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Sotomayor EM; GW Cancer Center and.
Zheng X; Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

JCI Insight ; 4(24)2019 12 19.

Article in En | MEDLINE | ID: mdl-31852841

Subject(s)

Adenocarcinoma of Lung/pathology; Biomarkers, Tumor/metabolism; Lung Neoplasms/pathology; Nerve Growth Factors/metabolism; Tumor Suppressor Proteins/metabolism; A549 Cells; Adenocarcinoma of Lung/genetics; Adenocarcinoma of Lung/mortality; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor/analysis; Biomarkers, Tumor/genetics; Carcinogenesis/genetics; Carcinogenesis/pathology; Cell Proliferation/genetics; CpG Islands; DNA Methylation; Datasets as Topic; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Kaplan-Meier Estimate; Lung/pathology; Lung Neoplasms/genetics; Lung Neoplasms/mortality; Male; Mice; Middle Aged; Nerve Growth Factors/analysis; Nerve Growth Factors/genetics; Prognosis; Tumor Suppressor Proteins/analysis; Tumor Suppressor Proteins/genetics; Xenograft Model Antitumor Assays

Key words

Cell Biology; Lung cancer; Tumor suppressors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Tumor Suppressor Proteins / Adenocarcinoma of Lung / Lung Neoplasms / Nerve Growth Factors Type of study: Prognostic_studies Limits: Aged80 Language: En Journal: JCI Insight Year: 2019 Type: Article

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