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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
Henley, Zoë A; Amour, Augustin; Barton, Nick; Bantscheff, Marcus; Bergamini, Giovanna; Bertrand, Sophie M; Convery, Máire; Down, Kenneth; Dümpelfeld, Birgit; Edwards, Chris D; Grandi, Paola; Gore, Paul M; Keeling, Steve; Livia, Stefano; Mallett, David; Maxwell, Aoife; Price, Mark; Rau, Christina; Reinhard, Friedrich B M; Rowedder, James; Rowland, Paul; Taylor, Jonathan A; Thomas, Daniel A; Hessel, Edith M; Hamblin, J Nicole.
Affiliation
  • Bantscheff M; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Bergamini G; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Dümpelfeld B; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Grandi P; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Price M; In Vitro In Vivo Translation , GlaxoSmithKline R&D , David Jack Centre, Park Road , Ware SG12 0DP , U.K.
  • Rau C; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Reinhard FBM; Cellzome GmbH , GlaxoSmithKline , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
J Med Chem ; 63(2): 638-655, 2020 01 23.
Article in En | MEDLINE | ID: mdl-31855425
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Class I Phosphatidylinositol 3-Kinases / Class III Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Class I Phosphatidylinositol 3-Kinases / Class III Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article