Delaying Centrifugation and Freezing by Adding a Dihydropyrimidine Dehydrogenase Inhibitor Such as Gimeracil to Blood Sample Is Not a Valid Option to Simplify the Preanalytic Step for the Screening of Dihydropyrimidine Dehydrogenase Deficiency Using Uracilemia.

Launay, Manon; Nasser, Yara; Tholance, Yannick; Dellinger, Sandrine; Gonzalo, Philippe; Delavenne, Xavier

Launay, Manon; Nasser, Yara; Tholance, Yannick; Dellinger, Sandrine; Gonzalo, Philippe; Delavenne, Xavier.

Affiliation

Launay M; Department of Pharmacology, Toxicology and Blood Gases, University Hospital of Saint-Etienne, Saint-Etienne, France.
Nasser Y; Department of Pharmacology, Toxicology and Blood Gases, University Hospital of Saint-Etienne, Saint-Etienne, France.
Tholance Y; Department of Biochemistry, University Hospital of Saint-Etienne, Saint-Etienne, France.
Dellinger S; Department of Biochemistry, University Hospital of Saint-Etienne, Saint-Etienne, France.
Gonzalo P; CNRS UMR 5310, INSERM U1217, Synaptopathies and Autoantibodies, Institut NeuroMyoGene, University of Lyon, University Jean-Monnet, Saint-Étienne, France.
Delavenne X; Department of Pharmacology, Toxicology and Blood Gases, University Hospital of Saint-Etienne, Saint-Etienne, France.

Ther Drug Monit ; 42(2): 344-345, 2020 04.

Article in En | MEDLINE | ID: mdl-31855974

Subject(s)

Centrifugation/methods; Dihydropyrimidine Dehydrogenase Deficiency/diagnosis; Freezing; Specimen Handling/methods; Dihydrouracil Dehydrogenase (NADP)/antagonists & inhibitors; Humans; Pyridines/administration & dosage; Uracil/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Specimen Handling / Centrifugation / Dihydropyrimidine Dehydrogenase Deficiency / Freezing Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Ther Drug Monit Year: 2020 Type: Article Affiliation country: France

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