Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors.

Xu, Yu; Hao, Shu-Yi; Zhang, Xiu-Juan; Li, Wen-Bo; Qiao, Xue-Peng; Wang, Zi-Xiao; Chen, Shi-Wu

Xu, Yu; Hao, Shu-Yi; Zhang, Xiu-Juan; Li, Wen-Bo; Qiao, Xue-Peng; Wang, Zi-Xiao; Chen, Shi-Wu.

Affiliation

Xu Y; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Hao SY; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Zhang XJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Li WB; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Qiao XP; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Wang ZX; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Chen SW; School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address: chenshw@lzu.edu.cn.

Bioorg Med Chem Lett ; 30(3): 126885, 2020 02 01.

Article in En | MEDLINE | ID: mdl-31862411

Subject(s)

Aurora Kinase A/antagonists & inhibitors; Aurora Kinase B/antagonists & inhibitors; Protein Kinase Inhibitors/chemistry; Pyrimidines/chemistry; Apoptosis/drug effects; Aurora Kinase A/metabolism; Aurora Kinase B/metabolism; Binding Sites; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary; Pyrimidines/metabolism; Pyrimidines/pharmacology; Structure-Activity Relationship; bcl-2-Associated X Protein/metabolism

Key words

Anticancer; Apoptosis; Aurora kinase; Pyrimidine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Protein Kinase Inhibitors / Aurora Kinase A / Aurora Kinase B Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: China

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