Cytotoxic steroidal saponins from the rhizome of Anemarrhena asphodeloides.
Steroids
; 155: 108557, 2020 03.
Article
in En
| MEDLINE
| ID: mdl-31866546
ABSTRACT
Two novel steroidal saponins, timosaponin V and W (1 and 2), together with seven known steroidal saponins (3-9), were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, 1H-1H COSY, and NOESY), and MS analyses. The cytotoxic activities of the isolates were evaluated. Compound 1 showed a significant cytotoxic activity against MCF-7 and HepG2 cell lines with IC50 values of 2.16 ± 0.19 µM and 2.01 ± 0.19 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saponins
/
Steroids
/
Rhizome
/
Anemarrhena
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Steroids
Year:
2020
Type:
Article
Affiliation country:
China