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Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient.
Alamarat, Zain I; Babic, Jessica; Tran, Truc T; Wootton, Susan H; Dinh, An Q; Miller, William R; Hanson, Blake; Wanger, Audrey; Gary, Joshua L; Arias, Cesar A; Pérez, Norma.
Affiliation
  • Alamarat ZI; Department of Pediatrics, Division of Pediatric Infectious Diseases, UTHealth, McGovern Medical School, Houston, Texas, USA.
  • Babic J; Department of Pharmacy, Memorial Hermann Texas Medical Center, Houston, Texas, USA.
  • Tran TT; Division of Infectious Diseases, UT Health, McGovern Medical School, Houston, Texas, USA.
  • Wootton SH; Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), UTHealth, McGovern Medical School, Houston, Texas, USA.
  • Dinh AQ; Department of Pediatrics, Division of Pediatric Infectious Diseases, UTHealth, McGovern Medical School, Houston, Texas, USA.
  • Miller WR; Division of Infectious Diseases, UT Health, McGovern Medical School, Houston, Texas, USA.
  • Hanson B; Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), UTHealth, McGovern Medical School, Houston, Texas, USA.
  • Wanger A; Division of Infectious Diseases, UT Health, McGovern Medical School, Houston, Texas, USA.
  • Gary JL; Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), UTHealth, McGovern Medical School, Houston, Texas, USA.
  • Arias CA; Center for Infectious Diseases, UTHealth, School of Public Health, Houston, Texas, USA.
  • Pérez N; Division of Infectious Diseases, UT Health, McGovern Medical School, Houston, Texas, USA.
Antimicrob Agents Chemother ; 64(4)2020 03 24.
Article in En | MEDLINE | ID: mdl-31871075
ABSTRACT
We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum ß-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Surgical Wound Infection / Cephalosporins / Compassionate Use Trials / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Adolescent / Humans / Male Country/Region as subject: Africa Language: En Journal: Antimicrob Agents Chemother Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Surgical Wound Infection / Cephalosporins / Compassionate Use Trials / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Adolescent / Humans / Male Country/Region as subject: Africa Language: En Journal: Antimicrob Agents Chemother Year: 2020 Type: Article Affiliation country: United States