Oral repeated-dose toxicity studies of BIA 10-2474 in beagle dogs.

Hardisty, Jerry F; Harris, Stephen B; Hayes, Wallace A; Weber, Klaus

Hardisty, Jerry F; Harris, Stephen B; Hayes, Wallace A; Weber, Klaus.

Affiliation

Hardisty JF; EPL Inc., North Carolina, USA.
Harris SB; Stephen B. Harris Group, San Diego, USA.
Hayes WA; University of South Florida College and Michigan State University, USA.
Weber K; AnaPath GmbH, 4625, Oberbuchsiten, Switzerland. Electronic address: kweber@anapath.ch.

Regul Toxicol Pharmacol ; 111: 104555, 2020 Mar.

Article in En | MEDLINE | ID: mdl-31874201

Subject(s)

Anti-Bacterial Agents/toxicity; Behavior, Animal/drug effects; Cyclic N-Oxides/toxicity; Enzyme Inhibitors/toxicity; Lung/drug effects; Pyridines/toxicity; Administration, Oral; Amidohydrolases/antagonists & inhibitors; Amidohydrolases/metabolism; Animals; Anti-Bacterial Agents/administration & dosage; Cyclic N-Oxides/administration & dosage; Dogs; Dose-Response Relationship, Drug; Lung/pathology; Maximum Tolerated Dose; No-Observed-Adverse-Effect Level; Pyridines/administration & dosage

Key words

BIA 102474; Beagle dogs; Endocannabinoid system; Endogenous anandamide; Toxicology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Behavior, Animal / Cyclic N-Oxides / Enzyme Inhibitors / Lung / Anti-Bacterial Agents Limits: Animals Language: En Journal: Regul Toxicol Pharmacol Year: 2020 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google