Clinical management patterns of advanced and metastatic gastro-oesophageal carcinoma after fluoropyrimidine/platinum treatment in France, Germany, Spain and the United Kingdom.
Eur J Cancer Care (Engl)
; 29(2): e13213, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-31883156
ABSTRACT
OBJECTIVE:
To describe treatment patterns and resource utilisation in France, Germany, Spain and the United Kingdom (UK) in patients with unresectable locally advanced and/or metastatic gastro-oesophageal adenocarcinoma (GEA), who failed first-line fluoropyrimidine/platinum treatment.METHODS:
Treating physicians completed a web-based chart review (2013-2015). Eligible patients were ≥ 18 years old; had unresectable locally advanced and/or metastatic gastric adenocarcinoma including the gastro-oesophageal junction; received first-line fluoropyrimidine/platinum-based therapy; and had ≥ 3 months of follow-up after first-line discontinuation. Data were summarised descriptively for each country.RESULTS:
There were n = 201 patients in France, n = 202 in Germany, n = 208 in Spain and n = 200 in the UK whose charts were reviewed. Percentages of patients receiving second-line therapy were 55% (France), 48% (Germany), 54% (Spain) and 29% (UK). At the start of second-line therapy, most patients had an ECOG performance status of 1 (range 0-3). Second-line therapy was primarily monotherapy, but agents used varied within and across countries. Supportive care use and resource utilisation were frequent whether receiving additional therapy or not; >60% patients had clinic visits unrelated to chemotherapy administration, and > 30% has ≥ 1 hospital admission.CONCLUSIONS:
For the time of study, established GEA treatment guidelines were generally followed. However, therapies varied widely in the second-line setting.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palliative Care
/
Stomach Neoplasms
/
Practice Patterns, Physicians'
/
Adenocarcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Guideline Adherence
/
Esophagogastric Junction
Type of study:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
Europa
Language:
En
Journal:
Eur J Cancer Care (Engl)
Journal subject:
ENFERMAGEM
/
NEOPLASIAS
Year:
2020
Type:
Article
Affiliation country:
United kingdom