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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Shirakawa, Jun; Tajima, Kazuki; Okuyama, Tomoko; Kyohara, Mayu; Togashi, Yu; De Jesus, Dario F; Basile, Giorgio; Kin, Tatsuya; Shapiro, A M James; Kulkarni, Rohit N; Terauchi, Yasuo.
Affiliation
  • Shirakawa J; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. jshira-tky@umin.ac.jp.
  • Tajima K; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
  • Okuyama T; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
  • Kyohara M; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
  • Togashi Y; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
  • De Jesus DF; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Basile G; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Kin T; Clinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.
  • Shapiro AMJ; Clinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.
  • Kulkarni RN; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
  • Terauchi Y; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Diabetologia ; 63(3): 577-587, 2020 03.
Article in En | MEDLINE | ID: mdl-31897526
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sorbitol / Intercellular Signaling Peptides and Proteins / Cell Proliferation / Insulin-Secreting Cells Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Diabetologia Year: 2020 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sorbitol / Intercellular Signaling Peptides and Proteins / Cell Proliferation / Insulin-Secreting Cells Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Diabetologia Year: 2020 Type: Article Affiliation country: Japan