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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.
Henderson, Michael X; Sedor, Samantha; McGeary, Ian; Cornblath, Eli J; Peng, Chao; Riddle, Dawn M; Li, Howard L; Zhang, Bin; Brown, Hannah J; Olufemi, Modupe F; Bassett, Danielle S; Trojanowski, John Q; Lee, Virginia M Y.
Affiliation
  • Henderson MX; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: hendm@pennmedicine.upenn.edu.
  • Sedor S; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • McGeary I; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Cornblath EJ; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Peng C; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Riddle DM; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Li HL; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zhang B; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Brown HJ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Olufemi MF; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bassett DS; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical & Systems Engineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of
  • Trojanowski JQ; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Lee VMY; Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuron ; 105(5): 822-836.e7, 2020 03 04.
Article in En | MEDLINE | ID: mdl-31899072
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Parkinsonian Disorders / Alpha-Synuclein / Protein Aggregation, Pathological / Glucosylceramidase / Neurons Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2020 Type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Parkinsonian Disorders / Alpha-Synuclein / Protein Aggregation, Pathological / Glucosylceramidase / Neurons Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2020 Type: Article