Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1&#945;.

Martin, Praxedis; Palmer, Gaby; Rodriguez, Emiliana; Palomo, Jennifer; Lemeille, Sylvain; Goldstein, Jérémie; Gabay, Cem

Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.

Martin, Praxedis; Palmer, Gaby; Rodriguez, Emiliana; Palomo, Jennifer; Lemeille, Sylvain; Goldstein, Jérémie; Gabay, Cem.

Affiliation

Martin P; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva 4, Switzerland; and.
Palmer G; Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals, 1211 Geneva 4, Switzerland.
Rodriguez E; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva 4, Switzerland; and.
Palomo J; Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals, 1211 Geneva 4, Switzerland.
Lemeille S; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva 4, Switzerland; and.
Goldstein J; Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals, 1211 Geneva 4, Switzerland.
Gabay C; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva 4, Switzerland; and.

J Immunol ; 204(4): 967-979, 2020 02 15.

Article in En | MEDLINE | ID: mdl-31932497

Subject(s)

Alarmins/antagonists & inhibitors; Apoptosis/immunology; Interleukin 1 Receptor Antagonist Protein/metabolism; Interleukin-1alpha/antagonists & inhibitors; Psoriasis/immunology; Alarmins/immunology; Alarmins/metabolism; Animals; Disease Models, Animal; Female; Humans; Imiquimod/immunology; Interleukin 1 Receptor Antagonist Protein/immunology; Interleukin-1alpha/immunology; Interleukin-1alpha/metabolism; Keratinocytes/metabolism; Male; Mice; Mice, Knockout; Protein Isoforms/immunology; Protein Isoforms/metabolism; Psoriasis/diagnosis; Psoriasis/pathology; Severity of Illness Index; Signal Transduction/immunology; Skin/cytology; Skin/immunology; Skin/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Apoptosis / Interleukin 1 Receptor Antagonist Protein / Interleukin-1alpha / Alarmins Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunol Year: 2020 Type: Article

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