Application of spray freeze drying to theophylline-oxalic acid cocrystal engineering for inhaled dry powder technology.

Tanaka, Ryoma; Hattori, Yusuke; Otsuka, Makoto; Ashizawa, Kazuhide

Tanaka, Ryoma; Hattori, Yusuke; Otsuka, Makoto; Ashizawa, Kazuhide.

Affiliation

Tanaka R; Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
Hattori Y; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Otsuka M; Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
Ashizawa K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.

Drug Dev Ind Pharm ; 46(2): 179-187, 2020 Feb.

Article in En | MEDLINE | ID: mdl-31937148

Subject(s)

Crystallization/methods; Dry Powder Inhalers/methods; Freeze Drying/methods; Oxalic Acid/chemistry; Powders/chemistry; Theophylline/chemistry; Administration, Inhalation; Chemistry, Pharmaceutical/methods; Drug Compounding/methods; Humidity; Particle Size

Key words

Dry powder inhaler; chemometrics; cocrystal; green chemistry; in situ analysis; materials science; molecular complex; powder technology; solid-state; spray freeze drying

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Powders / Theophylline / Oxalic Acid / Crystallization / Dry Powder Inhalers / Freeze Drying Language: En Journal: Drug Dev Ind Pharm Year: 2020 Type: Article Affiliation country: Japan

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