Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF<sup>V600E</sup> by synergistically decreasing global trimethylation of H3K27.

Fu, Hao; Cheng, Lin; Sa, Ri; Jin, Yuchen; Chen, Libo

Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF^V600E by synergistically decreasing global trimethylation of H3K27.

Fu, Hao; Cheng, Lin; Sa, Ri; Jin, Yuchen; Chen, Libo.

Affiliation

Fu H; Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Cheng L; Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Sa R; Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Jin Y; Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Chen L; Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

J Cell Mol Med ; 24(6): 3336-3345, 2020 03.

Article in En | MEDLINE | ID: mdl-31970877

Subject(s)

Benzamides/pharmacology; Biphenyl Compounds/pharmacology; Cell Differentiation/drug effects; Histones/metabolism; Morpholines/pharmacology; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins B-raf/genetics; Pyridones/pharmacology; Thyroid Cancer, Papillary/drug therapy; Benzimidazoles/pharmacology; Cell Line, Tumor; Drug Resistance, Neoplasm/genetics; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors; Gene Expression Regulation, Neoplastic/drug effects; Humans; Imidazoles/pharmacology; Iodine Radioisotopes/metabolism; Methylation/drug effects; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Oximes/pharmacology; Thyroid Cancer, Papillary/genetics; Thyroid Gland/pathology

Key words

EZH2 inhibitor; H3K27me3; MAPK inhibitor; differentiation therapy; thyroid cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Benzamides / Biphenyl Compounds / Histones / Cell Differentiation / Morpholines / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Thyroid Cancer, Papillary Limits: Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: China

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