Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production.

Truman, Lucy A; Bentley, Kevin L; Ruddle, Nancy H

Truman, Lucy A; Bentley, Kevin L; Ruddle, Nancy H.

Affiliation

Truman LA; ENT Department, West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, UK.
Bentley KL; Yale School of Public Health, New Haven, CT, USA.
Ruddle NH; Yale School of Public Health, New Haven, CT, USA.

Eur J Immunol ; 50(3): 418-425, 2020 03.

Article in En | MEDLINE | ID: mdl-32012252

Subject(s)

Lacrimal Apparatus/pathology; Lymphadenopathy/pathology; Lymphotoxin-alpha/metabolism; Salivary Glands/pathology; Tertiary Lymphoid Structures/pathology; Animals; Lymphadenopathy/genetics; Lymphoma, B-Cell, Marginal Zone/genetics; Lymphoma, B-Cell, Marginal Zone/immunology; Lymphoma, B-Cell, Marginal Zone/pathology; Lymphotoxin-alpha/genetics; Mice; Mice, Transgenic; Sjogren's Syndrome/genetics; Sjogren's Syndrome/immunology; Sjogren's Syndrome/pathology; Tears/metabolism; Tertiary Lymphoid Structures/genetics

Key words

MALT-Lymphoma; Sjögren's syndrome; lymphotoxin; tertiary lymphoid organ; transgenic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Glands / Lymphotoxin-alpha / Tertiary Lymphoid Structures / Lymphadenopathy / Lacrimal Apparatus Limits: Animals Language: En Journal: Eur J Immunol Year: 2020 Type: Article Affiliation country: United kingdom

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