Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.

Singh, Sunil; Sivaraman, J

Singh, Sunil; Sivaraman, J.

Affiliation

Singh S; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.
Sivaraman J; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.

Biochem J ; 477(5): 905-923, 2020 03 13.

Article in En | MEDLINE | ID: mdl-32039437

Subject(s)

Protein Domains/physiology; Ubiquitin-Protein Ligases/chemistry; Ubiquitin-Protein Ligases/metabolism; Ubiquitination/physiology; Crystallization/methods; Humans; Protein Structure, Secondary; Ubiquitin-Protein Ligases/genetics

Key words

E3-ubiquitin ligase; HECT type domain; autoubiquitination; cancer; protein degradation; structure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Ubiquitination / Protein Domains Limits: Humans Language: En Journal: Biochem J Year: 2020 Type: Article Affiliation country: Singapore

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