Kringles of substrate plasminogen provide a 'catalytic switch' in plasminogen to plasmin turnover by Streptokinase.

Sharma, Vandna; Kumar, Shekhar; Sahni, Girish

Sharma, Vandna; Kumar, Shekhar; Sahni, Girish.

Affiliation

Sharma V; Division of Protein Science & Engineering, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
Kumar S; Division of Protein Science & Engineering, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
Sahni G; Division of Protein Science & Engineering, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.

Biochem J ; 477(5): 953-970, 2020 03 13.

Article in En | MEDLINE | ID: mdl-32069359

Subject(s)

Catalytic Domain/physiology; Fibrinolysin/metabolism; Kringles/physiology; Plasminogen/metabolism; Streptokinase/metabolism; Catalysis; Fibrinolysin/chemistry; Fluorescence Resonance Energy Transfer/methods; Humans; Plasminogen/chemistry; Protein Structure, Secondary; Streptokinase/chemistry; Substrate Specificity/physiology

Key words

catalysis; enzyme activity; fluorescence resonance energy transfer; plasminogen; streptokinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen / Streptokinase / Fibrinolysin / Kringles / Catalytic Domain Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem J Year: 2020 Type: Article Affiliation country: India

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