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Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.
Ponzi, Simona; Bresciani, Alberto; Kaiser, Marcel; Nardi, Valentina; Nizi, Emanuela; Ontoria, Jesus M; Pace, Paola; Paonessa, Giacomo; Summa, Vincenzo; Harper, Steven.
Affiliation
  • Ponzi S; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy. Electronic address: s.ponzi@irbm.com.
  • Bresciani A; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Nardi V; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Nizi E; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Ontoria JM; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Pace P; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Paonessa G; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Summa V; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
  • Harper S; Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.
Bioorg Med Chem Lett ; 30(8): 127052, 2020 04 15.
Article in En | MEDLINE | ID: mdl-32113841
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Trypanocidal Agents / Trypanosoma cruzi / Drug Discovery / Growth Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Trypanocidal Agents / Trypanosoma cruzi / Drug Discovery / Growth Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article