Engineering light-controllable CAR T cells for cancer immunotherapy.

Huang, Ziliang; Wu, Yiqian; Allen, Molly E; Pan, Yijia; Kyriakakis, Phillip; Lu, Shaoying; Chang, Ya-Ju; Wang, Xin; Chien, Shu; Wang, Yingxiao

Huang, Ziliang; Wu, Yiqian; Allen, Molly E; Pan, Yijia; Kyriakakis, Phillip; Lu, Shaoying; Chang, Ya-Ju; Wang, Xin; Chien, Shu; Wang, Yingxiao.

Affiliation

Huang Z; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Wu Y; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Allen ME; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Pan Y; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Kyriakakis P; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Lu S; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Chang YJ; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Wang X; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Chien S; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Wang Y; Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Sci Adv ; 6(8): eaay9209, 2020 02.

Article in En | MEDLINE | ID: mdl-32128416

Subject(s)

Immunotherapy, Adoptive; Light; Neoplasms/immunology; Neoplasms/therapy; Receptors, Chimeric Antigen/metabolism; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; T-Lymphocytes/radiation effects; Animals; Antigens, CD19/immunology; Antigens, Neoplasm/immunology; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Cell Line; Cryptochromes/genetics; Cryptochromes/metabolism; Cytotoxicity, Immunologic/immunology; Cytotoxicity, Immunologic/radiation effects; Humans; Immunotherapy, Adoptive/methods; Lymphocyte Activation/genetics; Lymphocyte Activation/immunology; Lymphocyte Activation/radiation effects; Mice; Models, Biological; Protein Binding; Protein Multimerization; Receptors, Chimeric Antigen/genetics; Transcriptional Activation/radiation effects; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Immunotherapy, Adoptive / Receptors, Chimeric Antigen / Light / Neoplasms Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2020 Type: Article Affiliation country: United States

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