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Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis.
Khan, Haaris S; Nair, Vidhya R; Ruhl, Cody R; Alvarez-Arguedas, Samuel; Galvan Rendiz, Jorge L; Franco, Luis H; Huang, Linzhang; Shaul, Philip W; Kim, Jiwoong; Xie, Yang; Mitchell, Ron B; Shiloh, Michael U.
Affiliation
  • Khan HS; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Nair VR; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Ruhl CR; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Alvarez-Arguedas S; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Galvan Rendiz JL; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Franco LH; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
  • Huang L; Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
  • Shaul PW; Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States.
  • Kim J; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, United States.
  • Xie Y; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, United States.
  • Mitchell RB; Harold C Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States.
  • Shiloh MU; Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, United States.
Elife ; 92020 03 05.
Article in En | MEDLINE | ID: mdl-32134383
ABSTRACT
Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scavenger Receptors, Class B / Mycobacterium tuberculosis Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Elife Year: 2020 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scavenger Receptors, Class B / Mycobacterium tuberculosis Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Elife Year: 2020 Type: Article Affiliation country: United States