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Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Shu, Youheng; Diamond, Tracy L; Hershey, James C; Huang, Shaei; Magliaro, Brian C; O'Brien, Julie A; Schlegel, Kelly-Ann S; Puri, Vanita; Uebele, Victor N; Uslaner, Jason M; Wang, Cheng; Converso, Antonella.
Affiliation
  • Shu Y; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Diamond TL; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Hershey JC; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA.
  • Huang S; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Magliaro BC; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • O'Brien JA; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Schlegel KS; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Puri V; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA.
  • Uebele VN; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA.
  • Uslaner JM; Neuroscience Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA.
  • Wang C; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Converso A; Departments of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: antonella_converso@merck.com.
Bioorg Med Chem Lett ; 30(9): 127066, 2020 05 01.
Article in En | MEDLINE | ID: mdl-32173198
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Drug Discovery Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Drug Discovery Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: United States