Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.

Hollborn, Margrit; Brück, Ricarda; Kuhrt, Heidrun; Wiedemann, Peter; Bringmann, Andreas

Hollborn, Margrit; Brück, Ricarda; Kuhrt, Heidrun; Wiedemann, Peter; Bringmann, Andreas.

Affiliation

Hollborn M; Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany.
Brück R; Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany.
Kuhrt H; Institute of Anatomy, University of Leipzig, Germany.
Wiedemann P; Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany.
Bringmann A; Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany.

Mol Vis ; 26: 188-203, 2020.

Article in En | MEDLINE | ID: mdl-32214785

Subject(s)

Cell Hypoxia/drug effects; Epithelial Cells/metabolism; Osmotic Pressure/drug effects; Osteopontin/metabolism; Purinergic Agonists/pharmacology; Receptors, Purinergic/metabolism; Retina/metabolism; Retinal Pigment Epithelium/metabolism; Adenosine Triphosphate/pharmacology; CREB-Binding Protein/genetics; CREB-Binding Protein/metabolism; Cell Hypoxia/genetics; Cells, Cultured; Epithelial Cells/drug effects; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/metabolism; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Humans; Osteopontin/genetics; Osteopontin/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Phospholipases A2/metabolism; RNA, Small Interfering; Retinal Pigment Epithelium/cytology; Retinal Pigment Epithelium/drug effects; Signal Transduction/drug effects; Signal Transduction/genetics; Sodium Chloride/pharmacology; Transcription Factors/genetics; Transcription Factors/metabolism; Vascular Endothelial Growth Factor A/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osmotic Pressure / Retina / Cell Hypoxia / Receptors, Purinergic / Epithelial Cells / Osteopontin / Retinal Pigment Epithelium / Purinergic Agonists Limits: Humans Language: En Journal: Mol Vis Journal subject: BIOLOGIA MOLECULAR / OFTALMOLOGIA Year: 2020 Type: Article Affiliation country: Germany

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