Molecular binding scaffolds increase local substrate concentration enhancing the enzymatic hydrolysis of VX nerve agent.

Lang, Xuye; Hong, Xiao; Baker, Cetara A; Otto, Tamara C; Wheeldon, Ian

Lang, Xuye; Hong, Xiao; Baker, Cetara A; Otto, Tamara C; Wheeldon, Ian.

Affiliation

Lang X; Chemical and Environmental Engineering Department, University of California, Riverside, California.
Hong X; Biochemistry Department, University of California, Riverside, California.
Baker CA; U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, Maryland.
Otto TC; U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, Maryland.
Wheeldon I; Chemical and Environmental Engineering Department, University of California, Riverside, California.

Biotechnol Bioeng ; 117(7): 1970-1978, 2020 07.

Article in En | MEDLINE | ID: mdl-32239488

Subject(s)

Chemical Warfare Agents/metabolism; Nerve Agents/metabolism; Organothiophosphorus Compounds/metabolism; Animals; Binding Sites; Cell Line; Chemical Warfare Agents/chemistry; DNA/chemistry; DNA/metabolism; Gene Expression; Humans; Hydrolysis; Nanostructures/chemistry; Nanotechnology; Phosphoric Triester Hydrolases/chemistry; Phosphoric Triester Hydrolases/metabolism; Substrate Specificity

Key words

DNA nanotechnology; bioconjugation; enzyme engineering; enzyme microenvironment; organophosphates

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Chemical Warfare Agents / Nerve Agents Limits: Animals / Humans Language: En Journal: Biotechnol Bioeng Year: 2020 Type: Article

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