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Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Fontaine, Valérie; Monteiro, Elodie; Fournié, Mylène; Brazhnikova, Elena; Boumedine, Thinhinane; Vidal, Cécile; Balducci, Christine; Guibout, Louis; Latil, Mathilde; Dilda, Pierre J; Veillet, Stanislas; Sahel, José-Alain; Lafont, René; Camelo, Serge.
Affiliation
  • Fontaine V; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Monteiro E; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Fournié M; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Brazhnikova E; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Boumedine T; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Vidal C; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Balducci C; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Guibout L; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Latil M; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Dilda PJ; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Veillet S; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Sahel JA; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
  • Lafont R; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
  • Camelo S; Biophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Aging (Albany NY) ; 12(7): 6151-6171, 2020 04 07.
Article in En | MEDLINE | ID: mdl-32255762
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinoids / Carotenoids / Photoreceptor Cells, Vertebrate / Stargardt Disease / Macular Degeneration Limits: Animals Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Type: Article Affiliation country: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinoids / Carotenoids / Photoreceptor Cells, Vertebrate / Stargardt Disease / Macular Degeneration Limits: Animals Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Type: Article Affiliation country: France