Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

Zheng, Min; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi

Zheng, Min; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi.

Affiliation

Zheng M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Karki R; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Vogel P; Animal Resources Center and the Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: thirumala-devi.kanneganti@stjude.org.

Cell ; 181(3): 674-687.e13, 2020 04 30.

Article in En | MEDLINE | ID: mdl-32298652

Subject(s)

Caspase 6/immunology; Caspase 6/metabolism; Inflammasomes/immunology; Animals; Apoptosis/immunology; Cell Death/immunology; Immunity, Innate; Inflammasomes/metabolism; Inflammasomes/physiology; Inflammation/immunology; Inflammation/metabolism; Inflammation/pathology; Macrophages/immunology; Macrophages/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Necroptosis/immunology; Protein Binding; Pyroptosis/immunology; RNA-Binding Proteins/metabolism; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

Key words

AAMs; NLRP3; PANoptosis; RIPK1; RIPK3; ZBP1; apoptosis; caspase-1; caspase-6; caspase-8; inflammasome; influenza A virus; necroptosis; pyroptosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspase 6 / Inflammasomes Limits: Animals Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: United States

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