Synthesis of 2'-deoxy-2'-fluoro-2'-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase.

Singh, Uma S; Chu, Chung K

Singh, Uma S; Chu, Chung K.

Affiliation

Singh US; Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, College of Pharmacy, Athens, Georgia, USA.
Chu CK; Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, College of Pharmacy, Athens, Georgia, USA.

Nucleosides Nucleotides Nucleic Acids ; 39(1-3): 52-68, 2020.

Article in En | MEDLINE | ID: mdl-32310031

Subject(s)

Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Hepacivirus/drug effects; Uridine/chemical synthesis; Uridine/pharmacology; Viral Nonstructural Proteins/antagonists & inhibitors; Humans; Microbial Sensitivity Tests; Molecular Structure; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Structure-Activity Relationship; Uridine/analogs & derivatives; Virus Replication/drug effects

Key words

2'-deoxy-2'-fluoro-2'-C-methyl spiro cyclopentyl nucleoside; Hepatitis C virus; carbocyclic nucleosides; phosphoramidate prodrug

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Uridine / Viral Nonstructural Proteins / Hepacivirus Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2020 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google