Deficit of circulating CD19+ CD24hi CD38hi regulatory B cells in severe aplastic anaemia.

Zaimoku, Yoshitaka; Patel, Bhavisha A; Kajigaya, Sachiko; Feng, Xingmin; Alemu, Lemlem; Quinones Raffo, Diego; Groarke, Emma M; Young, Neal S

Deficit of circulating CD19⁺ CD24^hi CD38^hi regulatory B cells in severe aplastic anaemia.

Zaimoku, Yoshitaka; Patel, Bhavisha A; Kajigaya, Sachiko; Feng, Xingmin; Alemu, Lemlem; Quinones Raffo, Diego; Groarke, Emma M; Young, Neal S.

Affiliation

Zaimoku Y; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Patel BA; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Kajigaya S; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Feng X; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Alemu L; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Quinones Raffo D; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Groarke EM; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Young NS; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.

Br J Haematol ; 190(4): 610-617, 2020 08.

Article in En | MEDLINE | ID: mdl-32311088

Subject(s)

ADP-ribosyl Cyclase 1/analysis; Anemia, Aplastic/blood; Antigens, CD19/analysis; B-Lymphocyte Subsets/pathology; B-Lymphocytes, Regulatory/pathology; CD24 Antigen/analysis; Lymphopenia/etiology; Membrane Glycoproteins/analysis; Adolescent; Adult; Aged; Anemia, Aplastic/complications; Anemia, Aplastic/drug therapy; Anemia, Aplastic/pathology; Antilymphocyte Serum/therapeutic use; B-Lymphocyte Subsets/chemistry; B-Lymphocytes, Regulatory/chemistry; Benzoates/therapeutic use; Bone Marrow/pathology; CD4-Positive T-Lymphocytes/pathology; CD8-Positive T-Lymphocytes/pathology; Cyclosporine/therapeutic use; Female; Humans; Hydrazines/therapeutic use; Immunosuppressive Agents/therapeutic use; Interleukin-10/biosynthesis; Interleukin-10/genetics; Killer Cells, Natural/pathology; Lymphocyte Count; Lymphopenia/blood; Lymphopenia/pathology; Male; Middle Aged; Pyrazoles/therapeutic use; Receptors, Thrombopoietin/agonists; Young Adult

Key words

aplastic anaemia; flow cytometry; immunosuppressive therapy; lymphocyte subsets; regulatory B cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / B-Lymphocyte Subsets / Antigens, CD19 / ADP-ribosyl Cyclase 1 / CD24 Antigen / B-Lymphocytes, Regulatory / Anemia, Aplastic / Lymphopenia Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Br J Haematol Year: 2020 Type: Article Affiliation country: United States

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