<i>Para</i>-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells.

Zhou, Xun; Bouitbir, Jamal; Liechti, Matthias E; Krähenbühl, Stephan; Mancuso, Riccardo V

Para-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells.

Zhou, Xun; Bouitbir, Jamal; Liechti, Matthias E; Krähenbühl, Stephan; Mancuso, Riccardo V.

Affiliation

Zhou X; Division of Clinical Pharmacology & Toxicology, University Hospital Basel, 4031 Basel, Switzerland.
Bouitbir J; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Liechti ME; Division of Clinical Pharmacology & Toxicology, University Hospital Basel, 4031 Basel, Switzerland.
Krähenbühl S; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Mancuso RV; Swiss Centre for Applied Human Toxicology, 4031 Basel, Switzerland.

Int J Mol Sci ; 21(8)2020 Apr 18.

Article in En | MEDLINE | ID: mdl-32325754

Subject(s)

Amphetamine/toxicity; Apoptosis/drug effects; Cell Differentiation/drug effects; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Neuroblastoma/metabolism; Adenosine Triphosphate/chemistry; Adenosine Triphosphate/metabolism; Amphetamine/chemistry; Amphetamine/metabolism; Amphetamines/metabolism; Amphetamines/toxicity; Cell Line, Tumor; Electron Transport/drug effects; Halogenation; Humans; Inhibitory Concentration 50; Methylamines/metabolism; Methylamines/toxicity; Mitochondria/metabolism; Oxygen Consumption/drug effects; Propiophenones/metabolism; Propiophenones/toxicity; Reactive Oxygen Species/metabolism; Superoxides/metabolism

Key words

amphetamine; methcathinone; mitochondria; neurotoxicity; para-halogenation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Apoptosis / Membrane Potential, Mitochondrial / Amphetamine / Mitochondria / Neuroblastoma Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Switzerland

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