Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD.

Heilig, Rosalie; Dilucca, Marisa; Boucher, Dave; Chen, Kaiwen W; Hancz, Dora; Demarco, Benjamin; Shkarina, Kateryna; Broz, Petr

Heilig, Rosalie; Dilucca, Marisa; Boucher, Dave; Chen, Kaiwen W; Hancz, Dora; Demarco, Benjamin; Shkarina, Kateryna; Broz, Petr.

Affiliation

Heilig R; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Dilucca M; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Boucher D; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Chen KW; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Hancz D; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Demarco B; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Shkarina K; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Broz P; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland petr.broz@unil.ch.

Life Sci Alliance ; 3(6)2020 06.

Article in En | MEDLINE | ID: mdl-32345661

Subject(s)

Apoptosis Regulatory Proteins/metabolism; BH3 Interacting Domain Death Agonist Protein/deficiency; Caspase 1/deficiency; Intracellular Signaling Peptides and Proteins/deficiency; Mitochondria/metabolism; Mitochondrial Proteins/metabolism; Phosphate-Binding Proteins/deficiency; Signal Transduction/genetics; Animals; Apoptosis/genetics; BH3 Interacting Domain Death Agonist Protein/genetics; Caspase 1/genetics; Cells, Cultured; Gene Editing; Gene Knockout Techniques; Inflammasomes/metabolism; Intracellular Signaling Peptides and Proteins/genetics; Macrophages/metabolism; Macrophages/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Membranes/metabolism; Necrosis/genetics; Necrosis/metabolism; Phosphate-Binding Proteins/genetics; Pyroptosis/genetics; Transfection

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Caspase 1 / Phosphate-Binding Proteins / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Apoptosis Regulatory Proteins / BH3 Interacting Domain Death Agonist Protein / Mitochondria Limits: Animals Language: En Journal: Life Sci Alliance Year: 2020 Type: Article Affiliation country: Switzerland

Fulltext

XML

PubMed Links

Search on Google