A peroxidase mimetic protects skeletal muscle cells from peroxide challenge and stimulates insulin signaling.

Eccardt, Amanda M; Pelzel, Ross J; Mattathil, Lyn; Moon, Yerin A; Mannino, Mark H; Janowiak, Blythe E; Fisher, Jonathan S

Eccardt, Amanda M; Pelzel, Ross J; Mattathil, Lyn; Moon, Yerin A; Mannino, Mark H; Janowiak, Blythe E; Fisher, Jonathan S.

Affiliation

Eccardt AM; Department of Biology, Saint Louis University, St. Louis, Missouri.
Pelzel RJ; Department of Biology, Saint Louis University, St. Louis, Missouri.
Mattathil L; Department of Biology, Saint Louis University, St. Louis, Missouri.
Moon YA; Department of Biology, Saint Louis University, St. Louis, Missouri.
Mannino MH; Department of Biology, Saint Louis University, St. Louis, Missouri.
Janowiak BE; Department of Biology, Saint Louis University, St. Louis, Missouri.
Fisher JS; Department of Biology, Saint Louis University, St. Louis, Missouri.

Am J Physiol Cell Physiol ; 318(6): C1214-C1225, 2020 06 01.

Article in En | MEDLINE | ID: mdl-32348172

Subject(s)

Antioxidants/pharmacology; Biological Mimicry; Hydrogen Peroxide/toxicity; Insulin Resistance; Insulin/pharmacology; Metalloporphyrins/pharmacology; Myoblasts, Skeletal/drug effects; Oxidative Stress/drug effects; Peroxidases/pharmacology; Animals; Cell Line; Glycogen Synthase Kinase 3 beta/metabolism; Hydrogen Peroxide/metabolism; Insulin Receptor Substrate Proteins/metabolism; Mice; Myoblasts, Skeletal/metabolism; Myoblasts, Skeletal/pathology; Phosphorylation; Protein Carbonylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction

Key words

AMPK; HyPer; glucose oxidase; ratiometric peroxide sensor

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peroxidases / Insulin Resistance / Oxidative Stress / Myoblasts, Skeletal / Biological Mimicry / Hydrogen Peroxide / Insulin / Metalloporphyrins / Antioxidants Limits: Animals Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google