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Evaluation of toxicity of aerosols from flavored e-liquids in Sprague-Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.
Ho, Jenny; Sciuscio, Davide; Kogel, Ulrike; Titz, Bjoern; Leroy, Patrice; Vuillaume, Gregory; Talikka, Marja; Martin, Elyette; Pospisil, Pavel; Lebrun, Stefan; Xia, Wenhao; Lee, Tom; Chng, Yun Xuan; Phillips, Blaine W; Veljkovic, Emilija; Guedj, Emmanuel; Xiang, Yang; Ivanov, Nikolai V; Peitsch, Manuel C; Hoeng, Julia; Vanscheeuwijck, Patrick.
Affiliation
  • Ho J; PMI S&I, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore, Singapore.
  • Sciuscio D; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Kogel U; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Titz B; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Leroy P; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Vuillaume G; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Talikka M; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Martin E; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Pospisil P; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Lebrun S; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Xia W; PMI S&I, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore, Singapore.
  • Lee T; PMI S&I, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore, Singapore.
  • Chng YX; PMI S&I, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore, Singapore.
  • Phillips BW; PMI S&I, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore, Singapore.
  • Veljkovic E; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Guedj E; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Xiang Y; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Ivanov NV; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Peitsch MC; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Hoeng J; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
  • Vanscheeuwijck P; PMI S&I, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Patrick.Vanscheeuwijck@pmi.com.
Arch Toxicol ; 94(6): 2179-2206, 2020 06.
Article in En | MEDLINE | ID: mdl-32367274
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Gene Expression Profiling / Transcriptome / Flavoring Agents / Electronic Nicotine Delivery Systems / Vaping / E-Cigarette Vapor / Liver Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Arch Toxicol Year: 2020 Type: Article Affiliation country: Singapore
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Gene Expression Profiling / Transcriptome / Flavoring Agents / Electronic Nicotine Delivery Systems / Vaping / E-Cigarette Vapor / Liver Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Arch Toxicol Year: 2020 Type: Article Affiliation country: Singapore