TMEM9-v-ATPase Activates Wnt/ß-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.

Jung, Youn-Sang; Stratton, Sabrina A; Lee, Sung Ho; Kim, Moon-Jong; Jun, Sohee; Zhang, Jie; Zheng, Biyun; Cervantes, Christopher L; Cha, Jong-Ho; Barton, Michelle C; Park, Jae-Il

Jung, Youn-Sang; Stratton, Sabrina A; Lee, Sung Ho; Kim, Moon-Jong; Jun, Sohee; Zhang, Jie; Zheng, Biyun; Cervantes, Christopher L; Cha, Jong-Ho; Barton, Michelle C; Park, Jae-Il.

Affiliation

Jung YS; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Stratton SA; Department of Life ScienceChung-Ang UniversitySeoulSouth Korea.
Lee SH; Department of Epigenetics and Molecular CarcinogenesisThe University of Texas MD Anderson Cancer CenterHoustonTX.
Kim MJ; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Jun S; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Zhang J; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Zheng B; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Cervantes CL; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Cha JH; Department of Experimental Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX.
Barton MC; Department of Biomedical SciencesCollege of MedicineInha UniversityIncheonSouth Korea.
Park JI; Department of Epigenetics and Molecular CarcinogenesisThe University of Texas MD Anderson Cancer CenterHoustonTX.

Hepatology ; 73(2): 776-794, 2021 02.

Article in En | MEDLINE | ID: mdl-32380568

Subject(s)

Adenomatous Polyposis Coli Protein/metabolism; Carcinoma, Hepatocellular/pathology; Liver Neoplasms/pathology; Membrane Proteins/metabolism; Vacuolar Proton-Translocating ATPases/metabolism; Adenomatous Polyposis Coli Protein/genetics; Animals; Carbon Tetrachloride/administration & dosage; Carbon Tetrachloride/toxicity; Carcinogenesis/pathology; Carcinoma, Hepatocellular/genetics; Cell Nucleus/metabolism; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/pathology; Disease Models, Animal; Gene Knockout Techniques; HEK293 Cells; Hep G2 Cells; Humans; Leupeptins/pharmacology; Liver Neoplasms/genetics; Liver Regeneration; Lysosomes/drug effects; Lysosomes/metabolism; Male; Membrane Proteins/genetics; Mice; Mice, Knockout; Proteolysis/drug effects; Wnt Signaling Pathway; Xenograft Model Antitumor Assays; beta Catenin/genetics; beta Catenin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Vacuolar Proton-Translocating ATPases / Adenomatous Polyposis Coli Protein / Liver Neoplasms / Membrane Proteins Type of study: Etiology_studies Limits: Animals / Humans / Male Language: En Journal: Hepatology Year: 2021 Type: Article

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