Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies.
Clin Transl Radiat Oncol
; 23: 30-34, 2020 Jul.
Article
in En
| MEDLINE
| ID: mdl-32382663
ABSTRACT
PURPOSE:
Recurrent head and neck cancers are associated with significant morbidity and mortality. Outcomes of multiple courses of radiation have not yet been described. METHODS AND MATERIALS A single institution database was queried to retrospectively review treatment plans and select patients who underwent ≥ 3 courses of radiation to the head and neck region.RESULTS:
Thirty-three patients were found to have ≥ 3 courses of radiation with overlapping fields. Median local recurrence free survival after last course of reirradiation was 9.1 months and median overall survival was 10 months. Grade 3 and above toxicities were reported in 15 patients (45%). Grade 4 and above toxicities were reported in seven patients (21%). There was no grade 5 toxicity. 20 patients (61%) underwent subsequent therapies following completion of repeat reirradiation.CONCLUSIONS:
Repeat reirradiation to the head and neck region is feasible and carries significant risks that are most appropriately managed with a multi-disciplinary team and must be balanced against the potential for local control and opportunities for emerging systemic therapies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Clin Transl Radiat Oncol
Year:
2020
Type:
Article
Affiliation country:
United States