Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide.

Lepland, Anni; Asciutto, Eliana K; Malfanti, Alessio; Simón-Gracia, Lorena; Sidorenko, Valeria; Vicent, Maria J; Teesalu, Tambet; Scodeller, Pablo

Lepland, Anni; Asciutto, Eliana K; Malfanti, Alessio; Simón-Gracia, Lorena; Sidorenko, Valeria; Vicent, Maria J; Teesalu, Tambet; Scodeller, Pablo.

Affiliation

Lepland A; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Asciutto EK; School of Science and Technology, National University of San Martin (UNSAM) and CONICET, Campus Migueletes, 25 de Mayo y Francia, San MartiÌn Buenos AiresCP 1650, Argentina.
Malfanti A; Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain.
Simón-Gracia L; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Sidorenko V; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Vicent MJ; Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain.
Teesalu T; Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14B, Tartu 50411, Estonia.
Scodeller P; Center for Nanomedicine and Department of Cell, Molecular and Developmental Biology, University of California, Santa Barbara, California 93106, United States.

Mol Pharm ; 17(7): 2518-2531, 2020 07 06.

Article in En | MEDLINE | ID: mdl-32421341

Subject(s)

Immunotherapy/methods; Lectins, C-Type/chemistry; Lung Neoplasms/diagnosis; Lymphatic Metastasis/diagnosis; Mannose-Binding Lectins/chemistry; Peptides/chemistry; Receptors, Cell Surface/chemistry; Triple Negative Breast Neoplasms/diagnosis; Tumor-Associated Macrophages/immunology; Animals; Binding Sites; Cell Differentiation; Cell Line, Tumor; Drug Carriers/administration & dosage; Drug Carriers/chemistry; Drug Carriers/metabolism; Drug Carriers/pharmacokinetics; Female; Fluorescence; Humans; Lectins, C-Type/immunology; Lectins, C-Type/metabolism; Lung Neoplasms/diagnostic imaging; Lung Neoplasms/pathology; Lung Neoplasms/secondary; Lymphatic Metastasis/diagnostic imaging; Lymphatic Metastasis/immunology; Lysosomes/metabolism; Maleimides/chemistry; Mannose Receptor; Mannose-Binding Lectins/immunology; Mannose-Binding Lectins/metabolism; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Peptides/administration & dosage; Peptides/metabolism; Peptides/pharmacokinetics; Polyesters/chemistry; Polyethylene Glycols/chemistry; Polymers/administration & dosage; Polymers/chemistry; Polymers/pharmacology; Receptors, Cell Surface/immunology; Receptors, Cell Surface/metabolism; Triple Negative Breast Neoplasms/diagnostic imaging; Triple Negative Breast Neoplasms/pathology; Tumor-Associated Macrophages/metabolism

Key words

CD206; drug delivery systems; homing peptide; immunotherapy; nanomedicine; pharmacokinetics; triple-negative breast cancer; tumor-associated macrophages

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Receptors, Cell Surface / Lectins, C-Type / Mannose-Binding Lectins / Triple Negative Breast Neoplasms / Tumor-Associated Macrophages / Immunotherapy / Lung Neoplasms / Lymphatic Metastasis Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2020 Type: Article Affiliation country: Estonia

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