Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR-mediated autophagy flux pathway.

Gu, Xiaohong; Li, Yuechun; Chen, Kaixin; Wang, Xingang; Wang, Zhongyu; Lian, Hao; Lin, Yuanzheng; Rong, Xing; Chu, Maoping; Lin, Jiafeng; Guo, Xiaoling

Gu, Xiaohong; Li, Yuechun; Chen, Kaixin; Wang, Xingang; Wang, Zhongyu; Lian, Hao; Lin, Yuanzheng; Rong, Xing; Chu, Maoping; Lin, Jiafeng; Guo, Xiaoling.

Affiliation

Gu X; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Li Y; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chen K; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang X; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang Z; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lian H; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lin Y; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Rong X; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chu M; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lin J; Center of Scientific Research, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Guo X; Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

J Cell Mol Med ; 24(13): 7515-7530, 2020 07.

Article in En | MEDLINE | ID: mdl-32424968

Subject(s)

AMP-Activated Protein Kinases/metabolism; Autophagy; Enterovirus B, Human/physiology; Exosomes/metabolism; Mesenchymal Stem Cells/metabolism; Myocarditis/metabolism; Myocarditis/virology; TOR Serine-Threonine Kinases/metabolism; Umbilical Cord/cytology; Animals; Apoptosis; Cell Line, Tumor; Exosomes/ultrastructure; Humans; Male; Mice, Inbred BALB C; Myocarditis/pathology; Myocarditis/physiopathology; Myocardium/pathology; Myocardium/ultrastructure; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology

Key words

AMPK; apoptosis; exosomes; human umbilical cord mesenchymal stem cells; mTOR-mediated autophagy flux; viral myocarditis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Umbilical Cord / Enterovirus B, Human / Exosomes / AMP-Activated Protein Kinases / TOR Serine-Threonine Kinases / Mesenchymal Stem Cells / Myocarditis Limits: Animals / Humans / Male Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: China

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