TLR2 and Dectin-1 Signaling in Mouse Hematopoietic Stem and Progenitor Cells Impacts the Ability of the Antigen Presenting Cells They Produce to Activate CD4 T Cells.

Martínez, Alba; Bono, Cristina; Gozalbo, Daniel; Goodridge, Helen S; Gil, M Luisa; Yáñez, Alberto

Martínez, Alba; Bono, Cristina; Gozalbo, Daniel; Goodridge, Helen S; Gil, M Luisa; Yáñez, Alberto.

Affiliation

Martínez A; Departamento de Microbiología y Ecología, and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, 46100 Burjassot, Spain.
Bono C; Departamento de Microbiología y Ecología, and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, 46100 Burjassot, Spain.
Gozalbo D; Departamento de Microbiología y Ecología, and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, 46100 Burjassot, Spain.
Goodridge HS; Board of Governors Regenerative Medicine Institute, and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Gil ML; Departamento de Microbiología y Ecología, and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, 46100 Burjassot, Spain.
Yáñez A; Departamento de Microbiología y Ecología, and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, 46100 Burjassot, Spain.

Cells ; 9(5)2020 05 25.

Article in En | MEDLINE | ID: mdl-32466296

Subject(s)

Antigen-Presenting Cells/metabolism; CD4-Positive T-Lymphocytes/immunology; Hematopoietic Stem Cells/metabolism; Lectins, C-Type/metabolism; Lymphocyte Activation/immunology; Signal Transduction; Toll-Like Receptor 2/metabolism; Animals; Antigen-Presenting Cells/drug effects; CD4-Positive T-Lymphocytes/drug effects; Candida albicans/immunology; Cytokines/metabolism; Hematopoietic Stem Cells/drug effects; Histocompatibility Antigens Class II/metabolism; Lipopeptides/pharmacology; Lymphocyte Activation/drug effects; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin/immunology; Signal Transduction/drug effects; Th1 Cells/drug effects; Th1 Cells/immunology; Th17 Cells/drug effects; Th17 Cells/immunology; Zymosan/pharmacology

Key words

CD4 T cells; Dectin-1; TLR2; antigen presenting cells; hematopoietic stem and progenitor cells; innate immune memory

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Lymphocyte Activation / CD4-Positive T-Lymphocytes / Signal Transduction / Lectins, C-Type / Toll-Like Receptor 2 / Antigen-Presenting Cells Limits: Animals Language: En Journal: Cells Year: 2020 Type: Article Affiliation country: Spain

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