<i>Msx1</i> deficiency interacts with hypoxia and induces a morphogenetic regulation during mouse lip development.

Nakatomi, Mitsushiro; Ludwig, Kerstin U; Knapp, Michael; Kist, Ralf; Lisgo, Steven; Ohshima, Hayato; Mangold, Elisabeth; Peters, Heiko

Msx1 deficiency interacts with hypoxia and induces a morphogenetic regulation during mouse lip development.

Nakatomi, Mitsushiro; Ludwig, Kerstin U; Knapp, Michael; Kist, Ralf; Lisgo, Steven; Ohshima, Hayato; Mangold, Elisabeth; Peters, Heiko.

Affiliation

Nakatomi M; Biosciences Institute, Newcastle University, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK nktm-emb@umin.ac.jp heiko.peters50@gmail.com.
Ludwig KU; Division of Anatomy, Department of Health Promotion, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Knapp M; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.
Kist R; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany.
Lisgo S; Biosciences Institute, Newcastle University, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK.
Ohshima H; School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4BW, UK.
Mangold E; Biosciences Institute, Newcastle University, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK.
Peters H; Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan.

Development ; 147(21)2020 06 24.

Article in En | MEDLINE | ID: mdl-32467233

Subject(s)

Hypoxia/embryology; Hypoxia/metabolism; Lip/embryology; MSX1 Transcription Factor/deficiency; Morphogenesis; Animals; Bone Morphogenetic Protein 4/metabolism; Cleft Lip/embryology; Cleft Lip/genetics; Cleft Lip/pathology; Female; Gene Expression Regulation, Developmental; Genome; Homeodomain Proteins/metabolism; Humans; Hypoxia/genetics; MSX1 Transcription Factor/genetics; MSX1 Transcription Factor/metabolism; Mesoderm/embryology; Mesoderm/metabolism; Mice, Inbred C57BL; Morphogenesis/genetics; Mutation/genetics; Nose/embryology; Oxygen/metabolism; PAX9 Transcription Factor/metabolism; Phenytoin; Respiration; Up-Regulation/genetics

Key words

Cleft lip and palate; Hypoxia; Morphogenetic regulation; Msx1; Pax9

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MSX1 Transcription Factor / Lip / Hypoxia / Morphogenesis Limits: Animals / Female / Humans Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 2020 Type: Article

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