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Molecular Choreography of Acute Exercise.
Contrepois, Kévin; Wu, Si; Moneghetti, Kegan J; Hornburg, Daniel; Ahadi, Sara; Tsai, Ming-Shian; Metwally, Ahmed A; Wei, Eric; Lee-McMullen, Brittany; Quijada, Jeniffer V; Chen, Songjie; Christle, Jeffrey W; Ellenberger, Mathew; Balliu, Brunilda; Taylor, Shalina; Durrant, Matthew G; Knowles, David A; Choudhry, Hani; Ashland, Melanie; Bahmani, Amir; Enslen, Brooke; Amsallem, Myriam; Kobayashi, Yukari; Avina, Monika; Perelman, Dalia; Schüssler-Fiorenza Rose, Sophia Miryam; Zhou, Wenyu; Ashley, Euan A; Montgomery, Stephen B; Chaib, Hassan; Haddad, Francois; Snyder, Michael P.
Affiliation
  • Contrepois K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Wu S; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Moneghetti KJ; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia; Stanford Sports Cardiology, D
  • Hornburg D; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Ahadi S; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Tsai MS; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Metwally AA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Wei E; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Lee-McMullen B; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Quijada JV; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Chen S; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Christle JW; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Sports Cardiology, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Ellenberger M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Balliu B; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Taylor S; Pediatrics Department, Stanford University School of Medicine, Stanford, CA, USA.
  • Durrant MG; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Knowles DA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Choudhry H; Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Ashland M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Bahmani A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Enslen B; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Amsallem M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Kobayashi Y; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Avina M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Perelman D; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Schüssler-Fiorenza Rose SM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Zhou W; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Ashley EA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Undiagnosed Diseases, Stanford University, Stanford, CA, USA.
  • Montgomery SB; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Chaib H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Haddad F; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. Electronic address: fhaddad@stanford.edu.
  • Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. Electronic address: mpsnyder@stanford.edu.
Cell ; 181(5): 1112-1130.e16, 2020 05 28.
Article in En | MEDLINE | ID: mdl-32470399
ABSTRACT
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptom-limited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting blood-based biomarkers of peak oxygen consumption.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exercise / Energy Metabolism Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exercise / Energy Metabolism Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: United States