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Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.
Xu, Chen-Nian; Kong, Ling-Heng; Ding, Peng; Liu, Yang; Fan, Zhen-Ge; Gao, Er-He; Yang, Jian; Yang, Li-Fang.
Affiliation
  • Xu CN; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
  • Kong LH; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China; School of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.
  • Ding P; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
  • Liu Y; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
  • Fan ZG; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
  • Gao EH; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
  • Yang J; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. Electronic address: yangjian1212@hotmail.com.
  • Yang LF; Department of Anesthesiology, Xi'an Children's Hospital, Xi'an 710003, China. Electronic address: yanglf@fmmu.edu.cn.
Biochim Biophys Acta Mol Basis Dis ; 1866(10): 165848, 2020 10 01.
Article in En | MEDLINE | ID: mdl-32473999
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Cardiomegaly / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Autophagy-Related Protein 5 / Melatonin Limits: Animals Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Cardiomegaly / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Autophagy-Related Protein 5 / Melatonin Limits: Animals Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Type: Article Affiliation country: China