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Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair.
Rink, Svenja; Chatziparaskeva, Christina; Elles, Luisa; Pavlov, Stoyan; Nohroudi, Klaus; Bendella, Habib; Sarikcioglu, Levent; Manthou, Marilena; Dunlop, Sarah; Gordon, Tessa; Angelov, Doychin N.
Affiliation
  • Rink S; Department of Prosthetic Dentistry, School of Dental and Oral Medicine, University of Cologne, Germany.
  • Chatziparaskeva C; Department of Anatomy I, University of Cologne, Germany.
  • Elles L; Department of Anatomy I, University of Cologne, Germany.
  • Pavlov S; Department of Anatomy, Histology and Embryology, Medical University, Varna, Bulgaria.
  • Nohroudi K; Department of Anatomy I, University of Cologne, Germany.
  • Bendella H; Department of Neurosurgery, University of Witten/Herdecke, Cologne Merheim Medical Center (CMMC), Cologne, Germany.
  • Sarikcioglu L; Department of Anatomy, Akdeniz University, Antalya, Turkey.
  • Manthou M; Department of Histology and Embryology, Aristotle University Thessaloniki, Greece.
  • Dunlop S; School of Biological Sciences, The University of Western Australia, Australia.
  • Gordon T; Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Angelov DN; Department of Anatomy I, University of Cologne, Germany.
Muscle Nerve ; 62(3): 404-412, 2020 09.
Article in En | MEDLINE | ID: mdl-32497302
ABSTRACT

BACKGROUND:

After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono-innervated neuro-muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ-monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor-2 (FGF2) and brain-derived neurotrophic factor (BDNF) in denervated vibrissal muscles.

METHODS:

We used normally sighted rats (Wistar), in which NMJ-polyinnervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti-BDNF, and FGF2 at different postoperative periods after facial nerve injury.

RESULTS:

Rats receiving anti-BDNF+FGF2 showed low NMJ-polyinnervation and best recovery of whisking amplitude.

CONCLUSIONS:

Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vibrissae / Fibroblast Growth Factor 2 / Brain-Derived Neurotrophic Factor / Recovery of Function / Facial Nerve Injuries / Antibodies, Neutralizing / Nerve Regeneration Limits: Animals Language: En Journal: Muscle Nerve Year: 2020 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vibrissae / Fibroblast Growth Factor 2 / Brain-Derived Neurotrophic Factor / Recovery of Function / Facial Nerve Injuries / Antibodies, Neutralizing / Nerve Regeneration Limits: Animals Language: En Journal: Muscle Nerve Year: 2020 Type: Article Affiliation country: Germany