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Identification of type 2 diabetes loci in 433,540 East Asian individuals.
Spracklen, Cassandra N; Horikoshi, Momoko; Kim, Young Jin; Lin, Kuang; Bragg, Fiona; Moon, Sanghoon; Suzuki, Ken; Tam, Claudia H T; Tabara, Yasuharu; Kwak, Soo-Heon; Takeuchi, Fumihiko; Long, Jirong; Lim, Victor J Y; Chai, Jin-Fang; Chen, Chien-Hsiun; Nakatochi, Masahiro; Yao, Jie; Choi, Hyeok Sun; Iyengar, Apoorva K; Perrin, Hannah J; Brotman, Sarah M; van de Bunt, Martijn; Gloyn, Anna L; Below, Jennifer E; Boehnke, Michael; Bowden, Donald W; Chambers, John C; Mahajan, Anubha; McCarthy, Mark I; Ng, Maggie C Y; Petty, Lauren E; Zhang, Weihua; Morris, Andrew P; Adair, Linda S; Akiyama, Masato; Bian, Zheng; Chan, Juliana C N; Chang, Li-Ching; Chee, Miao-Li; Chen, Yii-Der Ida; Chen, Yuan-Tsong; Chen, Zhengming; Chuang, Lee-Ming; Du, Shufa; Gordon-Larsen, Penny; Gross, Myron; Guo, Xiuqing; Guo, Yu; Han, Sohee; Howard, Annie-Green.
Affiliation
  • Spracklen CN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Horikoshi M; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
  • Kim YJ; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
  • Lin K; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
  • Bragg F; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Moon S; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Suzuki K; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
  • Tam CHT; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
  • Tabara Y; Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
  • Kwak SH; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Takeuchi F; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Long J; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • Lim VJY; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Chai JF; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Chen CH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
  • Nakatochi M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Yao J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Choi HS; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Iyengar AK; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Perrin HJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Brotman SM; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • van de Bunt M; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Gloyn AL; Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Below JE; Biomedical Science, Hallym University, Chuncheon, South Korea.
  • Boehnke M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Bowden DW; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Chambers JC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Mahajan A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ng MCY; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Petty LE; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Zhang W; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
  • Morris AP; Stanford University, Stanford, CA, USA.
  • Adair LS; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Akiyama M; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Bian Z; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Chan JCN; Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Chang LC; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Chee ML; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Chen YI; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Chen YT; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.
  • Chen Z; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
  • Chuang LM; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
  • Du S; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Gordon-Larsen P; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Gross M; Genentech, South San Francisco, CA, USA.
  • Guo X; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Guo Y; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Han S; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
  • Howard AG; Genentech, South San Francisco, CA, USA.
Nature ; 582(7811): 240-245, 2020 06.
Article in En | MEDLINE | ID: mdl-32499647
ABSTRACT
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Asian People / Diabetes Mellitus, Type 2 Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Female / Humans / Male Country/Region as subject: Asia / Europa Language: En Journal: Nature Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Asian People / Diabetes Mellitus, Type 2 Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Female / Humans / Male Country/Region as subject: Asia / Europa Language: En Journal: Nature Year: 2020 Type: Article Affiliation country: United States