CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases.

Wong, Hiu Yi; Schwarz, Herbert

Wong, Hiu Yi; Schwarz, Herbert.

Affiliation

Wong HY; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore; Immunology Programme, Life Sciences Institute, National University of Singapore, 117456, Singapore.
Schwarz H; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore; Immunology Programme, Life Sciences Institute, National University of Singapore, 117456, Singapore. Electronic address: phssh@nus.edu.sg.

J Autoimmun ; 112: 102499, 2020 08.

Article in En | MEDLINE | ID: mdl-32505443

Subject(s)

4-1BB Ligand/metabolism; Autoimmune Diseases/drug therapy; Immunologic Factors/pharmacology; Signal Transduction/immunology; Tumor Necrosis Factor Receptor Superfamily, Member 9/metabolism; 4-1BB Ligand/antagonists & inhibitors; Animals; Autoimmune Diseases/immunology; Disease Models, Animal; Drug Evaluation, Preclinical/methods; Humans; Immunologic Factors/therapeutic use; Mice; Molecular Targeted Therapy/methods; Signal Transduction/drug effects; Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors

Key words

Autoimmunity; CD137; CD137L; Immunotherapy; Soluble CD137

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Signal Transduction / 4-1BB Ligand / Tumor Necrosis Factor Receptor Superfamily, Member 9 / Immunologic Factors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: Singapore

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